Abstract: Pressure sensitive paint is an advanced optical testing technology. The calibration error of paint is one of the main error sources of this technology. The measuring range of pressure sensitive paint is gradually expanding from the conventional pressure range to ultra-low pressure and ultra-high pressure. Therefore, it is necessary to develop a calibration system with a large pressure adjustment range and high precision. A new PSP wide range pressure calibration method and system are proposed by combining the existing method of variable pressure with the method of variable concentration. The performance difference between this system and ISSI's commercial calibration system is studied by theoretical calculation. The results show that the calibration error of the PSP wide range pressure calibration system in the low-pressure area (1-20 kPa) can be controlled within 0.5 kPa, and its performance is better than that of the ISSI calibration system. In the medium-pressure area (20-200 kPa), the error of this system is under 4%, which is close to that of the ISSI calibration system, and the error decreases with the increase of pressure. In the high-pressure area (200-600 kPa), it has a broader calibration range and can realize the calibration of PSP in an ultra-high-pressure environment (400-600 kPa). This paper also carried out calibration tests on the two most commonly used quick response PSPs. The results show that proposed system has high calibration accuracy and can realize the wide range calibration of PSP.