Abstract: Due to the characters of helicopter itself, the interaction effects of rotor wake on fuselage show obviously nonlinearity, and are correlate with several factors. Adopting a neural network is a better way to resolve a nonlinear problem. A neural network model can be built with experimental data which are constructed as a pattern set for training of net parameters.The neural network model may be used to research aerodlynamie characters of the interaction effects of rotor wake on fuselage, and the trained model can be directly used in the design of aerodynamics and real-time simulation for helicopter. In addition to analyze the neural net work modeling, the experiment about aerodynamic interaction effects of rotor wake on fuselage were simply introduced.