Abstract: The scientific experimental design method can significantly improve the quality and efficiency of scientific research and industrial production. This paper introduces and summarizes the research progress of modern test design methods. Firstly, this paper summarizes the differences between OFAT（One Fact at A Time） method and MDOE（Modern Design Of Experiments） method in the wind tunnel test in three aspects: the test purpose, organization strategy and test results, and analyzes the advantages of MDOE method. Secondly, it summarizes the status quo of the MDOE method in three aspects: the experimental design, model establish-ment and result analysis. Then we demonstrate the experimental design method with standard functions and aerodynamic examples. Finally, some key scientific problems and future research directions are discussed.