Abstract: The combination of bionics and drag reduction technology has opened up an important research direction in the field of drag reduction, and has made a significant breakthrough. For better implementation to reduce the wind resistance effect, this paper studies the composite micro-nano drag reduction structure, according to the principle of bionics, through CFD simulation combined with the laser micro-nano fabrication technology. A combined model of drag reduction structure wad established. The flight vehicle air sensor head surface with bionic sharkskin composite micro-nano structures was manufactured by laser interference scanning on the basis of the bionic sharkskin scale structures, to further improve the drag reduction performance. Through the parallel simulation and wind tunnel test, the drag reduction mechanism was theoretically analyzed, and the composite structures were manufactured with a drag reduction rate of up to 10.3%.