Abstract: Modern Design of Experiments （MDOE） is an important technical approach to improve wind tunnel test efficiency. Although the modern design of experiment method based on Latin Hypercube Sampling has high theoretical efficiency, the practical efficiency of the random sampling points designed by it decreases significantly when the automatic attitude control system of the wind tunnel model is coordinated. In this paper, a modern design of experiment method based on the Stratified Latin Hypercube design is proposed to meet the requirements of the multi-variable wind tunnel test design in the automatic attitude control system. It is applied to the two-variable test and three-variable test design of the 6 Mach number wind tunnel model. The results which were compared with the One Factor at A Time （OFAT） method show that MDOE method only needs about 20% of the sample size of OFAT method in the two-variable test and only needs about 30% of the sample size of OFAT method in the three-variable test. Compared with the classical Latin Hypercube method, the Stratified Latin Hypercube method developed in this paper combined with the existing wind tunnel test equipment can effectively reduce the change of test runs, improve the test efficiency and shorten the test period.