Abstract: In order to meet the demand of the development of advanced aerospace models in the future, the construction of large-scale transonic wind tunnels has been carried out. Since the construction of large-scale continuous transonic wind tunnels has never been carried out in the past, construction experience is limited. The estimation pressure loss of the continuous wind tunnel and the calculation of aerodynamic parameters of various parts are the design input conditions for the wind tunnel structure system, measurement and control system, and power system. The accuracy of pressure loss estimation results directly affects the difficulty of the wind tunnel power system design. Using the classical pressure loss calculation method combined with the CFD numerical simulation, this paper comprehensively analyzes the key parts of the loss and the results of scaled section test, and gives the loss coefficient of the special section, especially that of the test section, more accurately. The iterative calculation method gives the aerodynamic performance of each section accurately. Finally, by comparing the estimated value of the wind tunnel pressure loss with the test results of 0.6 m continuous wind tunnel, the estimated uncertainty is within 7.5%.