<i>In</i> <i>vitro</i> experimental simulation study of the hemodynamics based on the FDA benchmark model

XU KeWei; GAO Qi; WAN Min; ZHANG Ke

doi:10.11729/syltlx20230146

Article Contents

Article Navigation > Journal of Experiments in Fluid Mechanics > 2024 > Accepted Manuscript

XU K W, GAO Q, WAN M, et al. In vitro experimental simulation study of the hemodynamics based on the FDA benchmark model[J]. Journal of Experiments in Fluid Mechanics, doi: 10.11729/syltlx20230146

Citation:

XU K W, GAO Q, WAN M, et al. In vitro experimental simulation study of the hemodynamics based on the FDA benchmark model[J]. Journal of Experiments in Fluid Mechanics, doi: 10.11729/syltlx20230146

XU K W, GAO Q, WAN M, et al. In vitro experimental simulation study of the hemodynamics based on the FDA benchmark model[J]. Journal of Experiments in Fluid Mechanics, doi: 10.11729/syltlx20230146

Citation:

XU K W, GAO Q, WAN M, et al. In vitro experimental simulation study of the hemodynamics based on the FDA benchmark model[J]. Journal of Experiments in Fluid Mechanics, doi: 10.11729/syltlx20230146

PDF( 9202 KB)

In vitro experimental simulation study of the hemodynamics based on the FDA benchmark model

doi: 10.11729/syltlx20230146

XU KeWei^1
,,
GAO Qi^{1
,
,},
WAN Min²,
ZHANG Ke²

1.
School of Aeronautics and Astronautics, Zhejiang University, Hangzhou　310027, China
2.
Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan　250101, China

Received Date: 2023-10-31
Accepted Date: 2024-01-25
Rev Recd Date: 2024-01-09

Available Online: 2024-03-04

Abstract

Abstract

In order to study the hemodynamics of the coronary artery in vitro and to understand the mechanism of cardiovascular disease from the perspective of fluid mechanics, a mock circulatory loop with systemic circulation and coronary circulation was constructed. Combined with a variety of fluid measurement techniques, the hemodynamics of the benchmark nozzle model proposed by Food and Drug Administration (FDA) was studied in vitro under the condition of coronary flow. The location of thrombus in the nozzle model was qualitatively predicted by the platelet adhesion emulation technique using fluorescent particles. The flow field inside the nozzle model was captured by particle image velocimetry (PIV), and the relationship between the thrombus formation and hemodynamics at the corresponding location was quantitatively analyzed. The results show that fluorescent particles are easy to adhere to the wall of the model near the flow structure of the backward-facing step, and the flow field data show that the thrombus formation location is related to the low velocity region and reflux near the wall. In vitro platelet adhesion emulation and hemodynamic research can provide references for coronary thrombotic investigation and related medical device development.
- mock circulatory loop,
- FDA benchmark model,
- hemodynamics,
- thrombus,
- PIV

FullText(HTML)

References(22)

References

[1]	TSAO C W, ADAY A W, ALMARZOOQ Z I, et al. Heart disease and stroke statistics-2022 update: a report from the American heart association[J]. Circulation, 2022, 145(8): e153–e639. doi: 10.1161/CIR.0000000000001052
[2]	ADNAN G, SINGH D P, MAHAJAN K. Coronary Artery Thrombus[M]//Treasure Island (FL): StatPearls Publishing, 2022.
[3]	BURKE A P, KOLODGIE F D, FARB A, et al. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression[J]. Circulation, 2001, 103(7): 934–940. doi: 10.1161/01.cir.103.7.934
[4]	AMBROSE J A, SINGH M. Pathophysiology of coronary artery disease leading to acute coronary syndromes[J]. F1000Prime Reports, 2015, 7: 08. doi: 10.12703/P7-08
[5]	DAVIES M J, THOMAS A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death[J]. The New England Journal of Medicine, 1984, 310(18): 1137–1140. doi: 10.1056/NEJM198405033101801
[6]	SALAZAH A E. Experimental myocardial infarction[J]. Circulation Research, 1961, 9(6): 1351–1356. doi: 10.1161/01.res.9.6.1351
[7]	WILLERSON J T, GOLINO P, EIDT J, et al. Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications[J]. Circulation, 1989, 80(1): 198–205. doi: 10.1161/01.cir.80.1.198
[8]	CAPPON F, WU T T, PAPAIOANNOU T, et al. Mock circulatory loops used for testing cardiac assist devices: a review of computational and experimental models[J]. The International Journal of Artificial Organs, 2021, 44(11): 793–806. doi: 10.1177/03913988211045405
[9]	KHUDZARI A Z M, KADIR M R A, OSMAN K, et al. Mock circulatory loop for cardiovascular assist device testing[M]//DEWI D E O, HAU Y W, KHUDZARI A Z M, et al. Cardiovascular Engineering. Singapore: Springer, 2020: 177-200.
[10]	XU K W, GAO Q, WAN M, et al. Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies[J]. Frontiers in Physiology, 2023, 14: 1175919. doi: 10.3389/fphys.2023.1175919
[11]	PARK Y K, MITA Y, OKI E, et al. Quantitative Evaluation for Anastomotic Technique of Coronary Artery Bypass Grafting by using In-vitro Mock Circulatory System[C]//Proc of the 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2007: 2705-2708.
[12]	PARK Y K, MITA Y, OKI E, et al. Development of “Patient Robot”; Training Robot based on Quantitative Analysis of Surgical Technique[C]//Proc of the First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics. 2006: 318-322.
[13]	CALDERAN J, MAO W B, SIROIS E, et al. Development of an in vitro model to characterize the effects of transcatheter aortic valve on coronary artery flow[J]. Artificial Organs, 2016, 40(6): 612–619. doi: 10.1111/aor.12589
[14]	STOCK S, SCHARFSCHWERDT M, MEYER-SARAEI R, et al. In vitro coronary flow after transcatheter aortic valve-in-valve implantation: a comparison of 2 valves[J]. The Journal of Thoracic and Cardiovascular Surgery, 2017, 153(2): 255-263. E1.
[15]	HORNY L, CHLUP H, VESELY J, et al. In vitro coronary stent implantation: vessel wall-stent interaction[C]//JOBBÁGY Á. 5th European Conference of the International Federation for Medical and Biological Engineering: Vol. 37. Berlin, Heidelberg: Springer, 2011: 795-798.
[16]	HARIHARAN P, GIARRA M, REDDY V, et al. Multilaboratory particle image velocimetry analysis of the FDA benchmark nozzle model to support validation of computational fluid dynamics simulations[J]. Journal of Biomechanical Engineering, 2011, 133(4): 041002. doi: 10.1115/1.4003440
[17]	RABEN J S, HARIHARAN P, ROBINSON R, et al. Time-resolved particle image velocimetry measurements with wall shear stress and uncertainty quantification for the FDA nozzle model[J]. Cardiovascular Engineering and Technology, 2016, 7(1): 7–22. doi: 10.1007/s13239-015-0251-9
[18]	STEWART S F C, PATERSON E G, BURGREEN G W, et al. Assessment of CFD performance in simulations of an idealized medical device: results of FDA’s first computational interlaboratory study[J]. Cardiovascular Engineering and Technology, 2012, 3(2): 139–160. doi: 10.1007/s13239-012-0087-5
[19]	STIEHM M, WÜSTENHAGEN C, SIEWERT S, et al. Numerical simulation of pulsatile flow through a coronary nozzle model based on FDA’s benchmark geometry[J]. Current Directions in Biomedical Engineering, 2017, 3(2): 775–778. doi: 10.1515/cdbme-2017-0163
[20]	GUYTON A C, HALL J E. Textbook of medical physiology[M]. 11th ed. Philadelphia: Elsevier Saunders, 2006.
[21]	LIU G M, ZHANG Y, CHEN H B, et al. Platelet deposition estimation: a novel method for emulating the pump thrombosis potential of blood pumps[J]. Artificial Organs, 2020, 44(5): 465–472. doi: 10.1111/aor.13620
[22]	LIU G M, CHEN H B, HOU J F, et al. Platelet adhesion emulation: a novel method for estimating the device thrombosis potential of a ventricular assist device[J]. The International Journal of Artificial Organs, 2020, 43(4): 252–257. doi: 10.1177/0391398819885946